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Cyclobutanes

The molecular structure of cyclobutane has four carbon atoms, and its four carbon atoms are not in the same plane, which is the folded conformation of cyclobutane. Cyclobutane itself is not of commercial or biological interest, but more complex derivatives are important in biology and biotechnology. Currently, nine FDA-approved drugs contain the cyclobutane structure. From the perspective of therapeutic areas, cyclobutyl drugs are mainly distributed in popular areas such as tumors, neurological diseases, infectious diseases, endocrine and metabolic diseases.

3-oxocyclobutane-1-carboxylic acid

(1S,2S,3R,5S)-2,6,6-Trimethylbicyclo[3.1.1]heptane-2,3-diol

(1R,2R,3S,5R)-2,6,6-Trimethylbicyclo[3.1.1]heptane-2,3-diol

(3,3-Difluorocyclobutyl)methanol

7-Boc-7-azaspiro[3.5]nonane-2-Methanol

3-(HYDROXYMETHYL)CYCLOBUTAN-1-ONE

3-hydroxycyclobutan-1-one

Ethyl 3-hydroxycyclobutanecarboxylate

3-(2-Chlorophenyl)cyclobutanol

diethyl 3-hydroxycyclobutane-1,1-dicarboxylate

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

trans-Methyl 3-hydroxycyclobutanecarboxylate

2,2,4,4-Tetramethylcyclobutane-1,3-diol

trans-3-AMino-cyclobutaneMethanol hydrochloride

2-(3,3-Difluorocyclobutyl)ethanol

(6-Hydroxyspiro[3.3]hept-2-yl)-carbamic acid tert-butyl ester

3-Hydroxy-3-methylcyclobutanecarboxylic acid

3-((tert-Butyldimethylsilyl)oxy)cyclobutanol

1-Hydroxycyclobutanecarboxylic acid

3-(Benzyloxy)cyclobutanol

2-(1-Ethynylcyclobutyl)pyridine

[1-(2-methoxyethyl)cyclobutyl]methanol

bicyclo[1.1.1]pentane-1,3-dicarboxylic acid

3-(methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid