The Ubiquitin-proteasome system (UPS) is an important pathway for selective protein degradation.

Antibody-drug conjugates (ADCs) consist of monoclonal antibodies (Antibody) targeting tumor-specific or tumor-associated antigens coupled with different numbers of small molecule toxins (Payload) through a linker, combining the high targeting ability of monoclonal antibodies and the high activity of cytotoxins in tumor tissues. It has the dual advantages of high targeting of monoclonal antibodies and high activity of cytotoxic agents in tumor tissues, and has better efficacy than traditional antibody-based oncology drugs.

We sat down with some of the original team members from Schrödinger and Nimbus Therapeutics who led the tyrosine kinase 2 (TYK2) inhibitor program that resulted in NDI-034858, an oral, selective allosteric inhibitor being evaluated for the treatment of multiple autoimmune diseases following successful recent Phase 2b results in psoriasis. On December 24, 2022, Takeda entered into an agreement to acquire Nimbus Lakshmi, Inc., a wholly-owned subsidiary of Nimbus Therapeutics, and it’s TK2 inhibitor, NDI-034858, in a $6 billion deal, with $4 billion up front. Here they discuss the challenges they faced and how these were overcome to successfully develop a potential best-in-class medicine – because they had the right vision and mindset to do things very differently.

In this blog, I tell an important part of the scientific adventure story that led to the discovery a novel medicine called deucravacitinib (Sotyktu™). [Disclaimer: I am a full-time employee at Bristol Myers Squibb.

Cancer cells grow and divide out of control, and spread into surrounding tissues, causing genetic changes. Tobacco use, age and family history, human papillomavirus (HPV), overweight and obesity, and alcohol consumption are found be risk factors for cancer

Human immunodeficiency virus 1 (HIV) is a virus that attacks the immune system by destroying CD4+ T cells (a type of white blood cell that fights infection).

Aziridine derivatives are aza-analogs of epoxides. The aziridine functionality is a valuable intermediate in synthetic organic and medicinal chemistry.

Morpholine is among versatile and efficient synthetic building blocks in medicinal chemistry and pharmacological activities.

China’s drug development is gradually moving toward innovation and originality, with a majority of new drugs being small molecule drugs.

The 2022 3rd Asian Pharma Manufacturing Congress was Successfully Held in Shanghai

An aromatic ring is a hydrocarbon containing benzene or some other related ring structure.

The subsidiary, XFlow specializes in the application research of new catalysts and the development of flow chemistry technology.

Specialty Monomers Materials Supply Available

The China Pharmaceutical CMC Industry Chain Technology Exchange and Entrepreneurs and Scientists Summit Forum was held successfully in Hangzhou from September 15 to September 16, 2022.

The largest USA-based intermediates and API show, Pharma ChemOutsourcing 2022, opened in Parsippany, New Jersey on September 7, 2022. This 3-day conference was combined with the forum and brought together many industry leaders, renowned experts, and executives from the pharmaceuticals, biotechnology, chemical, and chemistry services industries to discuss changing landscape and future trends of the global pharmaceutical industry during the post-epidemic period. The panel discussions featured 5 main topics: 1) CMC, API & Global Supply Chain Security in the Post-Pandemic World 2) Choosing the Right CDMO for Biotechs: Past, Present, and Future 3) Small Molecule API Supply Chain Post-Pandemic: Price Inflation, CDMO Capacity Constraints, Raw Materials, Logistical Challenges 4) What's Going On In China? Risk Mitigation, Lockdowns, Ports, Shipping, Reshoring, Chinese Manufacturing Expansion in USA & Europe 5) Private Equity Investment in CDMO, which encouraged to explore emerging trends, key insights, and new collaborations in APIs after the outbreak.                         This was the second time that LinkChem participated in and sponsored ChemOutsourcing exhibition. As a fast-growing CDMO company in the pharmaceutical industry, LinkChem has always adhered to technology-driven and focused on the field of small molecule pharmaceutical, actively developing industrialized technologies to serve global customers. During the exhibition, LinkChem's products and services attracted many customers to visit booth No. 5. Our senior chemist, Dr. Zhong, made face-to-face in-depth communication with senior executives and scientists from well-known companies in the industry, presented innovative CRO and CMO strengths as well as the brand image to customers that gained positive feedback and potential purchase intentions. The conference improved our understanding of market dynamics and customer needs in the post-pandemic era, building a solid foundation for further international expansion. Meanwhile, LinkChem would accelerate towards the global pharmaceutical industry chain through the exhibition, realizing the internationalization strategy upgrade, and providing customers with more high-quality chemical custom service!                      LinkChem will continue to take the research, development and industrialization as the company's overall and long-term development strategy, aimed at actively contributing to the cause of life, health, and green energy innovation. LinkChem will continue to take the research, development and industrialization as the company's overall and long-term development strategy, aimed at actively contributing to the cause of life, health, and green energy innovation.The largest USA-based intermediates and API show, Pharma ChemOutsourcing 2022, opened in Parsippany, New Jersey on September 7, 2022. This 3-day conference was combined with the forum and brought together many industry leaders, renowned experts, and executives from the pharmaceuticals, biotechnology, chemical, and chemistry services industries to discuss changing landscape and future trends of the global pharmaceutical industry during the post-epidemic period. The panel discussions featured 5 main topics: 1) CMC, API & Global Supply Chain Security in the Post-Pandemic World 2) Choosing the Right CDMO for Biotechs: Past, Present, and Future 3) Small Molecule API Supply Chain Post-Pandemic: Price Inflation, CDMO Capacity Constraints, Raw Materials, Logistical Challenges 4) What's Going On In China? Risk Mitigation, Lockdowns, Ports, Shipping, Reshoring, Chinese Manufacturing Expansion in USA & Europe 5) Private Equity Investment in CDMO, which encouraged to explore emerging trends, key insights, and new collaborations in APIs after the outbreak.        This was the second time that LinkChem participated in and sponsored ChemOutsourcing exhibition. As a fast-growing CDMO company in the pharmaceutical industry, LinkChem has always adhered to technology-driven and focused on the field of small molecule pharmaceutical, actively developing industrialized technologies to serve global customers. During the exhibition, LinkChem's products and services attracted many customers to visit booth No. 5. Our senior chemist, Dr. Zhong, made face-to-face in-depth communication with senior executives and scientists from well-known companies in the industry, presented innovative CRO and CMO strengths as well as the brand image to customers that gained positive feedback and potential purchase intentions. The conference improved our understanding of market dynamics and customer needs in the post-pandemic era, building a solid foundation for further international expansion. Meanwhile, LinkChem would accelerate towards the global pharmaceutical industry chain through the exhibition, realizing the internationalization strategy upgrade, and providing customers with more high-quality chemical custom service!      LinkChem will continue to take the research, development and industrialization as the company's overall and long-term development strategy, aimed at actively contributing to the cause of life, health, and green energy innovation.

Benzene is a common organic compound. Small amounts of benzene are produced when materials containing carbon are burned incompletely. In recent decades, benzene has become increasingly popular mainly because it is an essential compound for making plastics.

LinkChem is honored to announce that Pharma Tech Outlook, awarded LinkChem among the Top 10 CROs in Asia and the Pacific. LinkChem was recognized in the five values of "quality of services, experience, capabilities, communication, and service cost".

The 8th BioCon-Antibody & PharmaCon (BPC) China 2022 Innovative Pharmaceuticals Thematic Conference was successfully held at Marriott Nanjing South Hotel on August 9th and August 10th. LinkChem participated with its pharmaceutical CRO and CDMO service outsourcing business, attracting a large number of visitors.

The 13th International Chemical Pharmaceutical Summit, hosted by Best Media and the Pharmaceutical Engineering Committee of China Pharmaceutical Association, came to a successful conclusion. LinkChem participated with its pharmaceutical R&D and manufacturing service outsourcing business, attracting many guests to visit.

Coumarins are a group of natural products that are widely distributed in nature and have important biological activities such as anti-inflammatory, anti-edema, anti-cancer, anti-tumour and immune enhancing, anti-oxidant, scavenging excess oxygen free radicals and protecting liver cells.