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Furazans

Incorporation of heterocycles into drug molecules can enhance physical properties and biological activity. Oxadiazoles are a class of five-membered heterocycles containing one oxygen and two nitrogen atoms with special biological activity and thermodynamic properties. 1,2,4- and 1,3,4-oxadiazoles are widely used in the development of bioactive molecules, but 1,2,5-oxadiazoles (furazans) are used relatively sparingly. Compared with 1,2,4- and 1,3,4-isomers, 1,2,5-oxadiazole has unique physicochemical properties and electronic effects. The furazan ring has a strong inductive effect, comparable to that of trifluoromethyl or tetrazolyl. The unique properties of furoxan can confer specific pharmacological activities to drug-like molecules.

(Z)-4-amino-N-hydroxy-1,2,5-oxadiazole-3-carbonimidoyl chloride

1,2,5-oxadiazole-3-carboxylic acid

(Z)-N-hydroxy-4-[(2-methoxyethyl)amino]-1,2,5-oxadiazole-3-carbonimidoyl chloride

3-(bromomethyl)-4-methyl-1,2,5-oxadiazole

3-methyl-4-nitro-1,2,5-oxadiazole

2-(4-methyl-1,2,5-oxadiazol-3-yl)acetic acid

ethyl 4-amino-1,2,5-oxadiazole-3-carboxylate

4-amino-1,2,5-oxadiazole-3-carbonitrile

dimethyl-1,2,5-oxadiazole

4-methyl-1,2,5-oxadiazole-3-carboxylic acid

4-iodo-1,2,5-oxadiazol-3-amine

3-(chloromethyl)-4-methyl-1,2,5-oxadiazole

1,2,5-oxadiazole-3,4-dicarboxylic acid

3-iodo-4-methyl-1,2,5-oxadiazole

4-amino-1,2,5-oxadiazole-3-carboxylic acid

4-methyl-1,2,5-oxadiazole-3-carbonitrile

3-methyl-1,2,5-oxadiazole

4-nitro-1,2,5-oxadiazole-3-carboxylic acid

methyl 1,2,5-oxadiazole-3-carboxylate

methyl 4-amino-1,2,5-oxadiazole-3-carboxylate

(4-methyl-1,2,5-oxadiazol-3-yl)methanol

1,2,5-oxadiazol-3-amine

(1,2,5-oxadiazol-3-yl)methanol

4-methoxy-1,2,5-oxadiazol-3-amine