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Thiadiazoles

Thiadiazoles are a subfamily of azoles. Structurally, they are five-membered heterocyclic compounds containing two nitrogen atoms and one sulfur atom, and two double bonds, forming an aromatic ring. Depending on the relative positions of the heteroatoms, there are four possible structures; these forms do not interconvert and are therefore structural isomers rather than tautomers. These compounds themselves are rarely synthesized and have no particular utility, however, compounds that use them as structural motifs are fairly common in pharmacology.

1-(1,3,4-thiadiazol-2-ylmethyl)cyclopropan-1-amine

2-(1,3,4-thiadiazol-2-yl)ethan-1-amine dihydrochloride

2-bromo-1,3,4-thiadiazole

dichloro-1,3,4-thiadiazole

bis(methylsulfanyl)-1,3,4-thiadiazole

1,3,4-thiadiazol-2-ylmethanamine hydrochloride

2-(5-methyl-1,3,4-thiadiazol-2-yl)ethan-1-amine

dimethanesulfonyl-1,3,4-thiadiazole

1,3,4-thiadiazole-2-carboxylic acid

4-amino-1,2,5-thiadiazole-3-carboxylic acid

4-[2-[1-(3-azetidinyl)-1h-pyrazol-5-yl]-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-n-1,3,4-thiadiazol-2-yl benzenesulfonamide

4,6-Difluorobenzo[c][1,2,5]thiadiazole

4-(Benzo[c][1,2,5]thiadiazol-5-ylmethoxy)benzaldehyde

(5-Methyl-1,3,4-thiadiazol-2-yl)methanamine

1,2,3-Thiadiazole-4-carbohydrazide

2-((5-Methyl-1,3,4-thiadiazol-2-yl)thio)acetic acid

N-[2-(4-methylphenyl)-3-phenyl-1,2,4-thiadiazol-5(2H)-ylidene]-methanamine monohydrobromide

Tizanidine hydrochloride

5-(trifluoromethyl)-1,3,4-thiadiazol-2-amine

5-isopropyl-1,3,4-thiadiazol-2-amine

5-tert-butyl-1,3,4-thiadiazol-2-amine

2,1,3-benzothiadiazol-4-amine

5-cyclohexyl-1,3,4-thiadiazol-2-amine

5-cyclopropyl-1,3,4-thiadiazol-2-amine