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  2. Category: Pyrimidines
  3. product Cas No.: 851443-04-4

Nombre del producto:ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

IUPAC Name:ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

CAS：851443-04-4
Fórmula molecular：C24H32FN3O6S
Pureza：95%
Número de catálogo：CM128418
Peso molecular：509.59
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Detalles del producto

Núm. De CAS :851443-04-4
Fórmula molecular:C24H32FN3O6S
Punto de fusión:-
Código de sonrisas:O=C(OCC)C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2
Densidad:
Número de catálogo:CM128418
Peso molecular:509.59
Punto de ebullición:699.1°C at 760 mmHg
Nº Mdl:MFCD12756003
Almacenamiento:Store at 2-8°C.

Category Infos

Pyrimidines
Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.

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Product Other Information

Product Overview Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is a medication prescribed by physicians to treat high cholesterol levels. It is a member of the statin class of drugs, which are used to reduce cholesterol levels by blocking the enzyme HMG-CoA reductase, which is responsible for producing cholesterol in the body. It is also used to reduce the risk of stroke, heart attack, and other cardiovascular diseases. Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is the generic name for the drug Crestor, which is manufactured by AstraZeneca.
Physical Properties Appearance: Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is a off-white to pale beige solid.
Solubility: The compound is slightly soluble in DMSO and methanol.
Chemical Properties Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is an intermediate in the production of super statin Resuvastatin calcium.
Synthesis and Application Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate has been studied extensively in clinical trials, and has been found to reduce LDL cholesterol levels, as well as total cholesterol levels. Additionally, it has been shown to reduce the risk of stroke, heart attack, and other cardiovascular diseases. Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate has also been studied in the laboratory setting, and has been found to have a number of beneficial effects on various biochemical and physiological processes.