Purines are heterocyclic aromatic compounds composed of linked pyrimidine and imidazole rings. In mammals, purines are most commonly expressed in DNA and RNA (including the purines adenine and guanine), as well as single-molecule nucleotides (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), cyclic AMP, and to a lesser extent guanosine triphosphate (GTP) and cyclic guanosine monophosphate (cGMP). Purines are also key elements of the following energy metabolism molecules: reduced nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate (NADPH), and coenzyme Q. Purines can also act as direct neurotransmitters; for example, adenosine may interact with receptors to modulate cardiovascular and central nervous system (CNS) function.
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Aziridines are highly strained three-membered heterocyclic molecules composed of one amine group and two carbon units. They are aza analogs of epoxides. Aziridines are a very important class of synthetic building blocks and intermediates in organic synthesis, which are widely used in organic synthesis, especially in the synthesis of nitrogen-containing natural products. Due to the high ring tension of aziridine, its reactivity is high. Under certain conditions, it can undergo cycloaddition reaction with various dipolar reagents to prepare some new nitrogen-containing heterocyclic compounds.
Aziridines are a very important class of synthetic building blocks and intermediates in organic synthesis
Aziridines,
Aziridines are highly strained three-membered heterocyclic molecules composed of one amine group and two carbon units. They are aza analogs of epoxides.
Tetrahydropyran is an organic compound consisting of a saturated six-membered ring containing five carbon atoms and one oxygen atom. Tetrahydropyrans are common structural motifs in natural products and synthetic therapeutic molecules. In nature, these six-membered oxygen heterocycles are usually assembled by intramolecular reactions, including oxygen Michael addition or ring opening of epoxy alcohols. In fact, polyether natural products have been particularly extensively studied for their fascinating structures and important biological properties; these are often formed through endoselective epoxy open cascades.
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