Quinoxalines, also known as benzopyrazines, are heterocyclic compounds containing a ring complex consisting of a benzene ring and a pyrazine ring. It has isomerism with other naphthalene compounds such as quinazoline, phthalazine, cinnamine, etc. Fusion N-heterocyclic compounds are widely used as valuable entities for the expansion of important pharmacological agents and are considered to be an advantageous scaffold material. Among the numerous fused N-heterocyclic compounds, cinnoline, quinoxaline and quinazoline are important pharmacological agents. In medicinal chemistry, these N-heterocyclic compounds have a wide range of biological properties and can be used as synthetic intermediates, potential drug candidates and chemical probes.
Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.
Cyclohexane is an organic compound with a chemical formula C6H12. It is a colorless liquid with a pungent odor, insoluble in water, and soluble in most organic solvents such as ethanol, ether, benzene, and acetone. Cyclohexyl fragments are a common structure in both natural and synthetic drugs. It can be used as both core structure and part of achiral side chain.
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