Nitrogen-containing heterocyclic compounds have a wide range of applications in medicine, organic materials, natural products and other fields, mainly for biologically active molecules. Pyrrolopyrazines contain pyrrole and pyrazine rings as bioactive scaffolds. Compounds containing this scaffold have a wide range of biological activities, such as antibacterial, anti-inflammatory, antiviral, antifungal, antioxidant, antitumor, and kinase inhibition.
Pyrazine is a heterocyclic aromatic organic compound with chemical formula C4H4N2. The marketed pyrazine drugs are mainly distributed in the field of anti-tumor and anti-infection. In recent years, there have been many new drugs in various fields, and there are some new target drugs worthy of attention.
Azaindole can be regarded as the biological isostere of indole, and the molecular unit of indole plays a huge role in the life process. Many drug molecules contain indole units. Azaindole is an important heterocyclic intermediate with good biological and medicinal value, and is the core structure of many drugs, such as antitumor drugs, dopamine D4 receptors, kinase inhibitors, thrombin inhibitors, etc. Therefore, it has a wide range of application value in medical research.
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