Nombre del producto:2-(8-ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

IUPAC Name:2-[8-ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

CAS:2621932-48-5
Fórmula molecular:C20H26BFO4
Pureza:95%+
Número de catálogo:CM1013587
Peso molecular:360.23

Unidad de embalaje Stock disponible Precio($) Cantidad
CM1013587-1g in stock ȀŢǯ
CM1013587-5g in stock ƄŢǯƞ

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Detalles del producto

Núm. De CAS :2621932-48-5
Fórmula molecular:C20H26BFO4
Punto de fusión:-
Código de sonrisas:CCC1=C(F)C=CC2=CC(OCOC)=CC(B3OC(C)(C)C(C)(C)O3)=C12
Densidad:
Número de catálogo:CM1013587
Peso molecular:360.23
Punto de ebullición:
Nº Mdl:
Almacenamiento:

Category Infos

Boronic Acids and Esters
Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry. Organoboron derivatives are common reagents for C–C bond formation, either through classical palladium-mediated transformations or through other newer coupling methods. Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API).
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Column Infos

HRS-4642
HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor, with an affinity constant of 0.083 nM. HRS-4642 demonstrated robust efficacy against KRAS G12D-mutant cancers both in vitro and in vivo. Importantly, in a phase 1 clinical trial, HRS-4642 exhibited promising anti-tumor activity in the escalating dosing cohorts. Furthermore, the sensitization and resistance spectrum for HRS-4642 was deciphered through genome-wide CRISPR-Cas9 screening, which unveiled proteasome as a sensitization target. HRS-4642, either as a single agent or in combination with carfilzomib, reshaped the tumor microenvironment toward an immune-permissive one.