Thienopyridines are similar in structure to quinoline and isoquinoline, and are a class of heterocyclic compounds with important physiological activity and medicinal value. Thienopyridines are a subclass of antiplatelet drugs that prevent platelet aggregation by binding to selected extracellular cysteine residues on the P2Y12 receptor located on the platelet membrane.
Potent IRAK-4 inhibitors have been reported by several groups including some structurally related benzimidazoles as well as alternative fused heterocycles such as the imidazopyridine and imidazopyridazine. Such compounds are reported to have IRAK-1 and IRAK-4 activity with varying degrees of selectivity.
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