Nombre del producto:2-Methoxy-4-(4-morpholinyl)-5-nitrobenzenamine

IUPAC Name:2-methoxy-4-(morpholin-4-yl)-5-nitroaniline

CAS:1903010-18-3
Fórmula molecular:C11H15N3O4
Pureza:95%+
Número de catálogo:CM1078119
Peso molecular:253.26

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Detalles del producto

Núm. De CAS :1903010-18-3
Fórmula molecular:C11H15N3O4
Punto de fusión:-
Código de sonrisas:O=N(=O)C1=CC(N)=C(OC)C=C1N2CCOCC2
Densidad:1.326±0.06 g/cm3
Número de catálogo:CM1078119
Peso molecular:253.26
Punto de ebullición:498.9±45.0 °C
Nº Mdl:
Almacenamiento:

Category Infos

Morpholines
Morpholine contains secondary amine groups and has all the typical reactive characteristics of secondary amine groups. It can react with inorganic acids to form salts, and react with organic acids to form salts or amides, which can be subjected to alkylation reaction, and can also be reacted with ethylene oxide, ketone or Willgerodt reaction. Morpholine is a six-membered ring containing oxygen and nitrogen, and its alkalinity is much lower than that of its parent piperidine. The marketed morpholine drugs are mainly distributed in the fields of tumors, cardiovascular and cerebrovascular diseases, respiratory system diseases, digestive system diseases, infectious diseases and mental disorders.
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Lazertinib
Johnson & Johnson announced new data from the Phase 2 PALOMA-2 study evaluating subcutaneous (SC) amivantamab combined with lazertinib as a first-line treatment in patients with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletion or L858R mutations. These data showed a comparable response rate in patients treated with SC amivantamab and lazertinib compared to those treated with the intravenous (IV) formulation in the MARIPOSA study, which established the combination of amivantamab and lazertinib as superior to osimertinib. Lazertinib is an oral, third-generation, brain-penetrant EGFR tyrosine kinase inhibitor (TKI) that targets both the T790M mutation and activating EGFR mutations while sparing wild type-EGFR.
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