Nombre del producto:tert-butyl N-(4-methylpiperidin-4-yl)carbamate

IUPAC Name:tert-butyl N-(4-methylpiperidin-4-yl)carbamate

Fórmula molecular:C11H22N2O2
Número de catálogo:CM103826
Peso molecular:214.31

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Detalles del producto

Núm. De CAS :163271-08-7
Fórmula molecular:C11H22N2O2
Punto de fusión:-
Código de sonrisas:CC(C)(C)OC(=O)NC1(C)CCNCC1
Número de catálogo:CM103826
Peso molecular:214.31
Punto de ebullición:308°C at 760 mmHg
Nº Mdl:MFCD08703167
Almacenamiento:Store at 2-8°C.

Category Infos

Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Column Infos

The Journal of Medicinal Chemistry recently publishes an article titled, “Discovery of Darovasertib, a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma”. Uveal melanoma (UM) is the most common primary intraocular malignancy. About half of primary uveal melanoma tumors metastasize but with no standard treatment. Most patients with metastatic uveal melanoma have been found to have mutations in GNAQ or GNA11, that are associated with consistent activation of the protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) pathways.
IDEAYA's Darovasertib (IDE196) is a potent, selective small molecule inhibitor of PKC which stops activating PKC/MEK pathway. Darovasertib is under Phase 2 expansion and Phase 3 registrational trial with Crizotinib in GNAQ/11 metastatic cutaneous melanoma.

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