Nombre del producto:(2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
IUPAC Name:(2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
| Unidad de embalaje | Stock disponible | Precio($) | Cantidad |
|---|---|---|---|
| CM338813-50mg | 5-6 Weeks | ǪľȃǙ |
|
|
|||
| Biological Activity |
VH 032 is an inhibitor of E3 ubiquitin ligase VHL (Kd = 185 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. VH 032 treatment causes dose dependent upregulation of HIF-target genes including CA9, GLUT1 and PHD2 in different cell lines. Cell permeable. |
| Technical Data |
Formula: C24H32N4O4S Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. CAS No: 1448188-62-2 |
| Use |
VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM. |
| Synonyms: |
VH032 CHEMBL3344081 1448188-62-2 (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide N-Acetyl-3-Methyl-L-Valyl-(4r)-4-Hydroxy-N-[4-(4-Methyl-1,3-Thiazol-5-Yl)benzyl]-L-Prolinamide VH-032 (2S,4R)-1-[(2S)-2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOYL]-4-HYDROXY-N~2~-[4-(4-METHYL-1,3-THIAZOL-5-YL)BENZYL]TETRAHYDRO-1H-PYRROLE-2-CARBOXAMIDE (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide 4w9h SCHEMBL15126287 EX-A6313 BDBM50099062 AKOS040749751 MS-28751 HY-120217 CS-0077220 EN300-26936924 Q27453846 Z3482164376 3JF |
| About Chemenu |
What We Offer: . Chemenu is a leading source of high-quality chemicals, providing a wide range of products for various industries, including pharmaceuticals, materials science, and research. . Our team specializes in developing custom chemical solutions to meet the unique needs of our customers. . We adhere to stringent quality control standards to ensure the purity and reliability of our products. . Chemenu invests in research and development, consistently pushing the boundaries of chemical science. . We are dedicated to sustainable practices and environmental responsibility in all our operations. Why Choose Chemenu: . Our unwavering commitment to quality sets us apart. You can trust our products and services. . We are always on the cutting edge of chemical advancements, providing solutions that drive progress. . Your satisfaction is our priority. We work closely with our customers to meet their specific needs. . We actively work towards a more sustainable future, reducing our impact on the environment. At Chemenu, we believe that chemistry has the power to transform the world. We invite you to explore our products and services, join us in our mission, and experience the chemistry of the future. Together, we can make a difference.For inquiries, partnership opportunities, and more, please don't hesitate to contact us. |
Buscar 
+86 21 5895 0110 
