cas 1365543-64-1|| where to buy benzenesulfonic acid;N-[cyclopropyl-oxo-[4-[[4-[(2R,3R)-3-phenylmethoxybutan-2-yl]oxy-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-lambda6-sulfanylidene]-2,2,2-trifluoroacetamide

Nombre del producto:benzenesulfonic acid;N-[cyclopropyl-oxo-[4-[[4-[(2R,3R)-3-phenylmethoxybutan-2-yl]oxy-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-lambda6-sulfanylidene]-2,2,2-trifluoroacetamide

IUPAC Name:N-[(R)-{4-[(4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl)amino]phenyl}(cyclopropyl)oxo-λ⁶-sulfanylidene]-2,2,2-trifluoroacetamide; benzenesulfonic acid

: CAS：1365543-64-1; Fórmula molecular：C33H32F6N4O7S2; Pureza：95%+

: Número de catálogo：CM664968; Peso molecular：774.75

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: Núm. De CAS :1365543-64-1; Fórmula molecular:C33H32F6N4O7S2; Punto de fusión:-; Código de sonrisas:OS(=O)(=O)C1=CC=CC=C1.C[C@@H](OCC1=CC=CC=C1)[C@@H](C)OC1=NC(NC2=CC=C(C=C2)[S@@](=O)(=NC(=O)C(F)(F)F)C2CC2)=NC=C1C(F)(F)F; Densidad:

: Número de catálogo:CM664968; Peso molecular:774.75; Punto de ebullición:; Nº Mdl:; Almacenamiento:

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: Pyrimidines; Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.

: Fluorinated Compounds; Fluorine is the most electronegative element in the periodic table, and the fluorine atom has a small atomic radius, so fluorine-containing organic compounds have many wonderful properties. For example, the introduction of fluorine atoms or fluorine-containing groups into drug molecules can improve the permeability to cell membranes, metabolic stability and bioavailability; in addition, the introduction of fluorine atoms will improve the lipid solubility of the compound and promote its absorption in the body. The speed of delivery changes the physiological effect. In the field of medicinal chemistry, the introduction of fluorine atoms into organic molecules is an important direction for the development of new anticancer drugs, antitumor drugs, antiviral agents, anti-inflammatory drugs, and central nervous system drugs.

: Cyclopropanes; Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

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