The molecular structure of cyclobutane has four carbon atoms, and its four carbon atoms are not in the same plane, which is the folded conformation of cyclobutane. Cyclobutane itself is not of commercial or biological interest, but more complex derivatives are important in biology and biotechnology. Currently, nine FDA-approved drugs contain the cyclobutane structure. From the perspective of therapeutic areas, cyclobutyl drugs are mainly distributed in popular areas such as tumors, neurological diseases, infectious diseases, endocrine and metabolic diseases.
Isothiazole or 1,2-thiazole is an organic compound containing a five-membered aromatic ring consisting of three carbon atoms, one nitrogen atom and one sulfur atom. In contrast to isomeric thiazoles, the two heteroatoms are in adjacent positions. The ring structure of isothiazoles is incorporated into larger compounds that are biologically active, such as the drugs ziprasidone and piperone. Isothiazoles are an important class of five-membered sulfur heterocyclic compounds that are widely used in medicinal chemistry and organic synthesis due to the unique properties of two electronegative heteroatoms in the 1,2-relationship.
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