Bridged ring compound refers to any two rings in the compound, which share two non-directly connected carbon atoms, and are classified into bicyclic hydrocarbons, tricyclic hydrocarbons, tetracyclic hydrocarbons, etc. Carbon atoms used in two or more rings are bridgehead carbon atoms, and the bond connecting the bridgehead carbon atoms is called a bridge. Bridged ring compounds are a class of organic compounds that are widely present in nature and usually have important physiological activities, such as the famous anticancer drug paclitaxel and antimalarial drug artemisinin.
bridged compounds,bridged bicyclic compounds
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Calico’s and AbbVie’s orally bioavailable eIF2B activator prodrug ABBV-CLS-7262 (fosigotifator) is being developed as a potential treatment for Vanishing White Matter disease (VWM), an ultra-rare progressive leukoencephalopathy. Accepted into the FDA’s START Pilot Program, ABBV-CLS-7262 is currently in an open-label Ph. I/II trial for adults and pediatrics with VWM disease and a randomized, double-blind Ph. I trial in patients with Amyotrophic Lateral Sclerosis (ALS). Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.
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