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Azepanes

The use of azepane as a scaffold for drug discovery remains of interest. The azepane linker is the key to efficient activity. A number of seven-membered ring derivatives have been prepared or investigated for their potential or actual pharmacological properties. Examples include azaalkane derivatives as PKB (protein kinase B) inhibitors.

tert-Butyl 3-oxoazepane-1-carboxylate

tert-butyl 4-oxoazepane-1-carboxylate

benzyl (5R)-5-methyl-1,4-diazepane-1-carboxylate

tert-butyl 4-hydroxyazepane-1-carboxylate

tert-butyl 4-aminoazepane-1-carboxylate

(5R)-1-benzyl-5-methyl-1,4-diazepane

4-methylazepan-4-ol hydrochloride

methyl azepane-4-carboxylate hydrochloride

4-methoxyazepane hydrochloride

1-[(tert-butoxy)carbonyl]azepane-4-carboxylic acid

4,4-difluoroazepane

tert-butyl 4-cyanoazepane-1-carboxylate

tert-butyl 4-(hydroxymethyl)azepane-1-carboxylate

4-methoxyazepane

(2R)-1-[(tert-butoxy)carbonyl]azepane-2-carboxylic acid

1-methylazepan-4-amine

4-fluoroazepane hydrochloride

(2s)-1-[(tert-butoxy)carbonyl]azepane-2-carboxylic acid

azepane-4-carbonitrile hydrochloride

1-tert-butyl 4-methyl azepane-1,4-dicarboxylate

1,4-diazepan-5-one hydrochloride

tert-butyl 4-formylazepane-1-carboxylate

tert-butyl N-(azepan-4-yl)carbamate

azepane-4-carboxylic acid